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Strength Training and Resveratrol
Resveratrol-mediated Changes in Extracellular Vesicle microRNA Cargo as a Novel Contributor to Resistance Training-induced Skeletal Muscle Adaptations in Older Adults
Who can join
Ages 60 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age 60+ * Minimally active (less than 1 hour of structured exercise/week other than walking) * No resistance training for the previous 6 months * Not currently taking resveratrol supplements * Stable medication, supplement, dietary, and physical activity regimens for the previous 3 months and no plans to change throughout the study period * Body mass at least 110 lbs Exclusion Criteria: * Medical complications that could increase risk during exercise (e.g., cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes, orthopedic contraindication to exercise, kidney disease, etc.) * Cannabis or nicotine use * Consume more than 7 alcohol-containing beverages per week
About the study
The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether circulating vehicles of inter-organ communication (extracellular vesicles) and their cargo might help explain those responses. The investigators will also examine whether resveratrol supplementation improves blood vessel function and cognitive function (brain health) in response to strength training.
What is being tested
- Resistance training (behavioral)
- Resveratrol 500 mg oral once daily. (dietary supplement)
- Placebo (dietary supplement)
Sponsor: Texas Tech University · Participants: 36 · Started: Jun 13, 2025
Contact the study team
- Danielle E Levitt, PhD · Phone: 806-834-1830
- Jacob A Mota, PhD · Phone: 806-834-8772
Official record on ClinicalTrials.gov — NCT06585865
Locations in the U.S.
| Texas | Department of Kinesiology & Sport Management, Texas Tech University, Lubbock |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.