Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke
RecruitingHealthy volunteers welcome
Mapping Corticoreticulospinal Motor Control Using Brainstem and Spinal Cord fMRI in Chronic Hemiparetic Stroke
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Adults aged at least 18y * Able to perform shoulder abduction task (confirmed during screening and initial examination) * Safe to undergo MRI * Able to follow visual instructions using MRI-compatible vision correction goggles * No brainstem or cerebellar lesions * No severe concurrent medical problems * Cognitive/attentional capacity to focus on a task * Able to communicate in English or Spanish Additional inclusion criteria for stroke participants: * Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project * Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45). Exclusion Criteria: * MRI contraindications * Severe claustrophobia * Pregnant women * Prisoners * Vulnerable populations * Diagnosis/history of: * multiple sclerosis * brain tumor * brain radiation * traumatic brain injury * dementia * Parkinson's disease * Concurrent enrollment in an intervention study * Concurrent use of medications known to suppress central nervous system activity
About the study
This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke.
What is being tested
- Shoulder Abduction (other)
Sponsor: Northwestern University · Participants: 32 · Started: May 20, 2023
Contact the study team
- Michelle Medina, BS · Phone: 872-272-7687
Official record on ClinicalTrials.gov — NCT06598150
Locations in the U.S.
| Illinois | Northwestern University, Chicago |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.