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Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease

RecruitingObservational study

A Cross-Sectional, Observational Study of the Prevalence of Adenoviral-Specific Antibodies and Inflammatory Cytokines in Participants With Chronic Granulomatous Disease

Who can join

All ages · All sexes

Full eligibility criteria
Inclusion Criteria:

* The participant must have been diagnosed with CGD based on the referring physician's confirmation that NADPH oxidase activity is ≤5% (i.e., the percentage of dihydrorhodamine-positive \[DHR+\] cells is ≤5% by flow cytometry) OR based on confirmed pathogenic mutation in a CGD associated gene (CYBB, CYBA, NCF1, NCF2, NCF4, or CYBC1).
* The participant or the participant's legally authorized guardian or representative (if applicable) must be capable of giving signed informed consent.
* The participant (with assistance from the participant's legally authorized guardian/representative or primary caregiver, if applicable) must be capable of complying with the requirements and restrictions listed in the protocol and informed consent form (ICF).

Exclusion Criteria:

* The participant has undergone an allogeneic bone marrow transplant or investigational gene therapy.
* The participant is unable to comply with the sample collection procedure based on investigator judgment.

About the study

This research study is designed to assess the prevalence of specific antibodies and inflammatory cytokines in adult and pediatric participants with CGD.

Sponsor: Ensoma · Participants: 60 · Started: Nov 18, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06605378

Locations in the U.S.

AlabamaHome-based telemedicine, Montgomery
ArizonaHome-based telemedicine, Phoenix
ArkansasHome-based telemedicine, Little Rock
CaliforniaHome-based telemedicine, Sacramento
University of California, San Francisco, San Francisco
ColoradoHome-based telemedicine, Denver
ConnecticutHome-based telemedicine, Hartford
DelawareHome-based telemedicine, Dover
District of ColumbiaHome-based telemedicine, Washington D.C.
FloridaHome-based telemedicine, Tallahassee
GeorgiaHome-based telemedicine, Atlanta
IdahoHome-based telemedicine, Boise
IllinoisHome-based telemedicine, Springfield
IndianaHome-based telemedicine, Indianapolis
IowaHome-based telemedicine, Des Moines
KansasHome-based telemedicine, Topeka
KentuckyHome-based telemedicine, Frankfort
LouisianaHome-based telemedicine, Baton Rouge
MaineHome-based telemedicine, Augusta
MarylandHome-based telemedicine, Annapolis
MassachusettsHome-based telemedicine, Boston
MichiganHome-based telemedicine, Lansing
MinnesotaHome-based telemedicine, Saint Paul
MississippiHome-based telemedicine, Jackson
MissouriHome-based telemedicine, Jefferson City
MontanaHome-based telemedicine, Helena
NebraskaHome-based telemedicine, Lincoln
NevadaHome-based telemedicine, Carson City
New HampshireHome-based telemedicine, Concord
New JerseyHome-based telemedicine, Trenton
New MexicoHome-based telemedicine, Santa Fe
New YorkHome-based telemedicine, Albany
North CarolinaScience 37, Inc, Morrisville
North DakotaHome-based telemedicine, Bismarck
OhioHome-based telemedicine, Columbus
OklahomaHome-based telemedicine, Oklahoma City
OregonHome-based telemedicine, Salem
PennsylvaniaHome-based telemedicine, Harrisburg
Rhode IslandHome-based telemedicine, Providence
South CarolinaHome-based telemedicine, Columbia
South DakotaHome-based telemedicine, Pierre
TennesseeHome-based telemedicine, Nashville
TexasHome-based telemedicine, Austin
UtahHome-based telemedicine, Salt Lake City
VermontHome-based telemedicine, Montpelier
VirginiaHome-based telemedicine, Richmond
WashingtonHome-based telemedicine, Olympia
West VirginiaHome-based telemedicine, Charleston
WisconsinHome-based telemedicine, Madison
WyomingHome-based telemedicine, Cheyenne

Conditions

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.