Home › Tobacco Use Cessation › NCT06609369

Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse

Who can join

Ages 18 to 65 · All sexes

Inclusion Criteria:

* English literate
* report heavy tobacco use (including nicotine e-cigarettes) for \>6 months
* meet biochemical cut off for recent cigarette smoking or e-cigarette use
* optimal body mass index

Exclusion Criteria:

* currently enrolled in other treatments
* neuropsychiatric exclusions that could interfere with study participation, increase risk of adverse events, and/or induce deficient sleep
* medical contraindications for fMRI, varenicline, and/or behavioral treatment
* factors that cause deficient sleep and for which behavioral treatment has less benefit
* women who are pregnant or nursing

About the study

The study aims to investigate whether behavioral interventions promote cessation in adult smokers by ameliorating negative emotions and improving self-control and identify the neural markers of these effects.

What is being tested

• Experimental health intervention (behavioral)
• Varenicline (drug)

Sponsor: Yale University · Participants: 114 · Started: Apr 21, 2025

Contact the study team

• Yu Chen, PhD · Phone: 347-819-2969
• Lisa Fucito, PhD · Phone: 203-200-1470

Official record on ClinicalTrials.gov — NCT06609369

Locations in the U.S.

Conditions

• Tobacco Use Cessation
• Insomnia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.