Home › Vaping › NCT06610838

Effects of E-cigarette Use on Health

Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health

Who can join

Ages 21 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* greater than or equal to 21 years of age
* has vaped a nicotine e-cigarette product at least 2 days/week for most weeks for greater than or equal to 12 months
* plans to remain in catchment area for greater than or equal to 3 years
* smoked 5 or fewer tobacco cigarettes in the past 6 months
* no serious CV, pulmonary, or other medical problems
* not currently pregnant
* no plans to stop vaping

Exclusion Criteria:

* serious CV, pulmonary, or other medical problems (e.g., moderate or severe aortic stenosis, class III or IV heart failure, blood pressure greater than or equal to 160/100 mmHg, interstitial lung disease, sarcoidosis, Stage 3 or 4 cancer)
* combusted or vaped cannabis use 3 days/week or more in the past 3 months
* currently pregnant
* not able to read an write English
* incarceration

About the study

Electronic nicotine delivery systems (ENDS) are used by millions of Americans, however their long-term health effects are unknown. This research proposal will quantify the effects of long-term ENDS use on validated and novel biomarkers of cardiovascular and pulmonary disease and how they are influenced by use heaviness, age, body weight, and co-use of other products. This study will produce the most informative evidence to date on how long-term ENDS use affects cardiovascular and pulmonary health.

What is being tested

• Health Assessments (other)

Sponsor: University of Wisconsin, Madison · Participants: 600 · Started: Jan 6, 2025

Contact the study team

• James Stein, MD · Phone: 608-262-2075
• Timothy Baker, PhD · Phone: 503-387-5167

Official record on ClinicalTrials.gov — NCT06610838

Locations in the U.S.

Conditions

• Vaping

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.