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Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium

Sevoflurane/Dexmedetomidine vs. Isoflurane and Their Effects on Pediatric Emergence Delirium

Who can join

Ages 2 to 7 · All sexes

Inclusion Criteria:

* Pediatric patients aged 2-7 years.
* Surgeries include ENT cases (i.e., tonsillectomy/adenoidectomy), ophthalmology cases (i.e., strabismus), and urology cases.
* Can be outpatient or General Care inpatient procedures.
* All cases must include an IV and an endotracheal tube (ETT).

Exclusion Criteria:

* Severe developmental/cognitive delay (unable to make eye contact, nonverbal, or inability to interact with providers for PAED scale assessment requirements)
* TIVA cases.
* No PIV in place during the case, planned PICU admission postoperatively.
* Previous history of severe emergence delirium documented by a provider (via interventions or explicitly stated).

About the study

The purpose of this study is to measure the incidences of pediatric emergence delirium between the group receiving Isoflurane and the group receiving Sevoflurane plus intravenous push dexmedetomidine.

What is being tested

• Sevoflurane (drug)
• Isoflurane (drug)

Sponsor: Mayo Clinic · Participants: 400 · Started: Dec 20, 2024

Contact the study team

• Lindsay Warner, MD · Phone: 507-284-2511
• Molly Herr, MD · Phone: 507-284-2511

Official record on ClinicalTrials.gov — NCT06624592

Locations in the U.S.

Conditions

• Emergence Delirium

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.