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Immune Status After Being on Call for 24 Hrs

Impact of a 24-hour Shift Call on the Immune Status of Surgery Residents

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Healthy subjects
* Surgery residents in a 24-hour shift rotation
* Gender of subjects: Males and females
* Age of subjects: 18 years old and older
* Racial and Ethnic Origin: Any race or ethnicity

Exclusion Criteria:

* Unwilling/unable to sign informed consent
* Vulnerable Subjects/Subject Capacity to provide consent

About the study

Sleep deprivation is a prevalent problem in modern societies. Sleep deprivation can cause hormonal changes, such as an increase in cortisol, as well as inflammation. Animal studies have shown an increase in inflammatory cytokine production following sleep deprivation. Additionally, humans experiencing sleep deprivation may experience a decrease in natural killer cells and lymphocytes.

Physicians, particularly those in surgical specialties, are often subjected to sleep deprivation as part of their medical residency training. This study hypothesizes that after 24-hour shifts, there is an increase in inflammatory response and impairment of the immune response against unspecific activation. This proposal aims to provide insight into the impact of sleep deprivation on the immune system of surgery residents by characterizing the phenotype and function of immune cells, as well as their correlation with biometric data.

What is being tested

• Blood Sample Collection (diagnostic test)
• Actigraph (GT9X-BT) Monitor (device)

Sponsor: University of Chicago · Participants: 60 · Started: Oct 17, 2024

Contact the study team

• Angelica Perez-Gutierrez, MD · Phone: 773-834-5087

Official record on ClinicalTrials.gov — NCT06636318

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.