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PrEP Readiness Interventions for Sustained Motivation (PRISM)

Optimizing HIV Prevention for Highly Vulnerable Methamphetamine-using Sexual Minority Men

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* 18 years or older
* Assigned male a birth
* Self-reported methamphetamine use in the past 3 months
* HIV-negative or unknown serostatus at baseline
* Has not filled a PrEP prescription in the past 6 months

Exclusion Criteria:

* Unwilling or unable to provide informed consent

About the study

This is a hybrid type I randomized controlled trial to test the effectiveness of contingency management (CM) alone versus CM with motivational interviewing (MI) for optimizing entry or re-entry into the HIV prevention or care continua. A total of 400 participants will be randomized to CM (n = 200) or MI+CM (n = 200), all delivered via telehealth. Monthly follow-up assessments will be completed over 12 months to examine effectiveness MI+CM for the primary outcome - filling a pre-exposure prophylaxis (PrEP) or anti-retroviral therapy (ART) prescription (verified using a digital photo). Secondary outcomes will include: self-reported PrEP or ART clinical evaluation by a provider; self-reported meth and other substance use severity (ASSIST), and self-reported receptive and insertive condomless anal sex (CAS).

What is being tested

• Motivational Interviewing (MI) (behavioral)
• Contingency Management (CM) (behavioral)

Sponsor: Florida International University · Participants: 400 · Started: Jan 28, 2025

Contact the study team

• Adam Carrico Professor, PhD · Phone: 305-348-7887

Official record on ClinicalTrials.gov — NCT06637436

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.