Home › NCT06638892

Using PrEP, Doing It for Ourselves

Cluster Randomized Controlled Trial of Using PrEP Doing It for Ourselves Protective Styles: A Multilevel Intervention to Improve HIV Testing and PrEP Uptake Among Southeastern U.S. At-risk Populations

Who can join

Ages 18 and older · Women · Healthy volunteers welcome

Inclusion Criteria:

* Black
* cisgender female
* Ages 18+

Exclusion Criteria:

* Under 18 years of age
* Does not identify as Black
* Not a cisgender female

About the study

The goal of this clinical trial is to test a new online program called UPDOs Protective Styles to help people in the southeastern United States learn about and start using PrEP (pre-exposure prophylaxis), a medicine that helps prevent HIV. The study focuses on people who may be at higher risk for HIV and have not had equal access to PrEP.

The main questions it aims to answer are:

Does UPDOs help more people trust and understand PrEP? Does UPDOs increase the number of people who start and continue using PrEP?

Researchers will compare two groups:

One group will use UPDOs, which includes six weekly videos, blog discussions, and access to telehealth services through Q Care Plus. The other group will receive standard HIV prevention materials from the CDC.

Participants will:

Be recruited from 32 beauty salons in areas with high HIV rates. Complete surveys at the start of the study and again at 6, 12, 24, 32, and 52 weeks.

Have access to HIV testing and PrEP prescriptions through Q Care Plus.

This study will also look at how well the program works in different communities and how easy it is to use and share.

What is being tested

• Using PrEP, Doing it for Ourselves (UPDOs) (behavioral)
• Standard of Care (other)

Sponsor: Duke University · Participants: 1,000 · Started: Feb 13, 2026

Contact the study team

• Niasha Fray, MA, MSPH · Phone: 919-668-8325
• Schenita Randolph, PhD · Phone: 919-684-3786

Official record on ClinicalTrials.gov — NCT06638892

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.