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Does Ethyl Chloride Spray Work?
Does "Freeze Spray" Work? Evaluating the Efficacy of Ethyl Chloride Usage Prior to Orthopaedic Injections
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * 18 years and older * Receiving a corticosteroid injection in an upper or lower extremity (to include soft tissue and joint injections) for the first time Exclusion Criteria: * Patients with previous injection experiences
About the study
A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal tunnel syndrome, trigger finger, and de Quervain's tenosynovitis. While these injections have demonstrated effectiveness in alleviating symptoms, the discomfort associated with the procedure can be a source of anxiety and apprehension for patients. This discomfort arises from the sensation of the needle entering the affected area and the burning sensation induced by the corticosteroid solution.
What is being tested
- Ethyl Chloride (other)
- Cold Saline Spray (other)
Sponsor: University of Chicago · Participants: 300 · Started: Apr 1, 2025
Contact the study team
- Jennifer M Wolf, MD, PhD · Phone: 773-834-3531
Official record on ClinicalTrials.gov — NCT06651788
Locations in the U.S.
| Illinois | University of Chicago, Chicago |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.