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Neonatal Platelet Transfusion Threshold Trial
RecruitingHealthy volunteers welcome
Who can join
1 Hour – 48 Hours · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Gestational age of 23 0/7 to 26 6/7 weeks * Postnatal age of \< 48 hours Exclusion Criteria: * Comfort care or withdrawal of care planned * Neonatal alloimmune thrombocytopenia or suspected/confirmed congenital platelet or bleeding disorder * Receipt of platelet transfusion * No receipt of Vitamin K * Parents/guardian decline consent
About the study
The objective of the NeoPlaTT trial is to test whether, among extremely preterm infants born at 23 0/7 to 26 6/7 weeks' gestation, a lower platelet transfusion threshold, compared to a higher threshold, improves survival without major or severe bleeding up to 40 0/7 weeks' postmenstrual age (PMA).
What is being tested
- Higher Platelet Transfusion Threshold (procedure)
- Lower Platelet Transfusion Threshold (procedure)
Sponsor: NICHD Neonatal Research Network · Participants: 2,433 · Started: Jun 13, 2025
Contact the study team
- Ravi M Patel, MD · Phone: 404-727-5905
- Abhik Das, PhD · Phone: 301-230-4640
Official record on ClinicalTrials.gov — NCT06676904
Locations in the U.S.
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.