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The SEQUENCE Trial

RecruitingHealthy volunteers welcome

The SEQUENCE Trial: Should Endobronchial Ultrasound QUeue bEfore or eNsuing to robotiC-assisted Bronchoscopy for pEripheral Pulmonary Nodule Biopsy?

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Peripheral Pulmonary Nodule undergoing a robotic-assisted bronchoscopy

Exclusion Criteria:

* lymph nodes that are enlarged or PET avid on CT prior to procedure

About the study

This study will randomize participants undergoing a bronchoscopic biopsy of a peripheral pulmonary nodule for their standard of care to receive robotic-assisted bronchoscopy (RaB) and then staging linear endobronchial ultrasounnd (EBUS) OR staging linear EBUS first, followed by RaB. The goal of this study is to set the standard for optimizing the sequence of bronchoscopic procedures in patients at risk for early-stage malignancy.

What is being tested

Sponsor: Northwestern University · Participants: 320 · Started: Nov 10, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06676956

Locations in the U.S.

CaliforniaUniversity of California, Davis, Sacramento
IllinoisNorthwestern University, Chicago
MarylandJohns Hopkins University, Baltimore
MichiganUniversity of Michigan, Ann Arbor
North CarolinaUniversity of North Carolina, Chapel Hill, Chapel Hill

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.