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Early Amiodarone in Shockable Cardiac Arrest

Early Amiodarone in Shockable Cardiac Arrest (Early-Amio) Study

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest
* Initial rhythm on EMS rhythm assessment of ventricular fibrillation or ventricular tachycardia
* Recurrence or persistence of ventricular fibrillation or ventricular tachycardia after one defibrillation attempt

Exclusion Criteria:

* Known allergy to amiodarone
* EMS-assessed contraindication to amiodarone
* Pre-existing "do-not-attempt-resuscitation" orders
* Inter-facility transportations
* Initial care by a non-participating EMS agency able to perform advanced life support interventions
* Pediatric patient as determined by EMS
* Prisoners
* Pregnant patients

About the study

The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initial dose of epinephrine) improves the time to amiodarone delivery in those with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or ventricular tachycardia compared to usual care.

What is being tested

• Amiodarone Hydrochloride Injection (drug)
• Usual Care Protocol (other)

Sponsor: Oregon Health and Science University · Participants: 585 · Started: Jan 1, 2025

Contact the study team

• Joshua Lupton, MD, MPH · Phone: (503) 418-6706

Official record on ClinicalTrials.gov — NCT06680869

Locations in the U.S.

Conditions

• Sudden Cardiac Arrest

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.