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Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Patient plans to have partial liver resection for primary liver pathology or metastatic disease * Patient is able to comprehend and willing to sign the written consent form Exclusion Criteria: * Patients \< 18 years * Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test
About the study
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.
What is being tested
- carbon monoxide measurement via smokerlyzer (other)
Sponsor: Englewood Hospital and Medical Center · Participants: 125 · Started: Nov 21, 2025
Contact the study team
- Jamie Ketas · Phone: 2018943418
Official record on ClinicalTrials.gov — NCT06681818
Locations in the U.S.
| New Jersey | Englewood Hospital, Englewood |
Conditions
From ClinicalTrials.gov, data retrieved Oct 3, 2026. Each study sets its own eligibility; the study team decides who can join.