Home › Female Infertility › NCT06686537

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women and Sheep

Who can join

Ages 18 to 38 · Women · Healthy volunteers welcome

Inclusion Criteria:

* Age 18-38
* Regular menstrual cycles every 25-35 days
* No use of reproductive hormones within the past 3 months
* No use of medications interacting with reproductive hormones
* Agreement to use reliable barrier contraception or to abstain from intercourse for the duration of the study
* Normal thyroid stimulating hormone, prolactin and lipid profiles
* No more than 4 hours of moderate to vigorous intensity exercise per week
* No history of chronic disease impacting reproductive hormones
* No contraindications to administration of estradiol
* No history of estrogen dependent cancer
* Negative pregnancy test

Exclusion Criteria:

* Has diabetes
* Is a smoker
* History of venous thromboembolism or known thrombophilia

About the study

Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.

What is being tested

• Estradiol Patches (drug)

Sponsor: University of Colorado, Denver · Participants: 20 · Started: Feb 25, 2025

Contact the study team

• Carrie Hsu · Phone: 303-724-5276

Official record on ClinicalTrials.gov — NCT06686537

Locations in the U.S.

Conditions

• Female Infertility
• Obesity
• Infertility

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.