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Investigating the Effects of Beef Consumption on Cognitive and Brain Health

Understanding the Cognitive and Brain Health Effects of Increasing Beef Consumption in Young Adults

Who can join

Ages 19 to 24 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Provision of signed and dated informed consent form
* Stated willingness to comply with all study procedures and lifestyle considerations and availability for the duration of the study
* Males and females; Age 19-24
* Willingness to adhere to the ready-to-eat beef intervention regimen
* Lives within 75 miles of Lincoln, NE
* BMI between 18.5 and 39.9
* Not pregnant or nursing
* No history of cognitive or metabolic diseases indicated by diagnosis, including neurodegenerative disease, stroke, Type 1 and 2 diabetes, metabolic syndrome, cardiovascular disease, liver disease, kidney disease, and cancer
* No history of eating or anxiety disorders
* Willing to discontinue dietary supplement use throughout the duration of the study, if they are consuming supplement at the time of the registration
* No known contraindication to MRI scans as determined by the MRI screening survey questions

Exclusion Criteria:

* Current use of medications that may affect their responses to dietary intervention, such as amphetamines, antidepressants, anti-diabetic medications, laxatives, antibiotics, statins and diuretics.
* Known intolerance or allergy to beef
* Current use of nicotine products, including vaping
* Previous use of nicotine products, including vaping, within the recent 6 months at the time of pre-screening

About the study

The goal of this clinical trial is to learn if eating more beef will lead to better cognition and a healthier brain in younger adults. The main questions it aims to answer are:

* Does eating more beef lead to higher scores on cognitive tests and better quality of life? * Does eating more beef lead to better brain function?

Researchers will compare participants in the experimental group (participants who will eat 25 ounces of beef every week during the dietary intervention) to control participants (participants who will eat 5 ounces of beef every week during the dietary intervention).

Participants will:

* Be instructed to prepare and consume ready-to-eat beef meals along with their regular diet and not eat any more beef other than what they are given * Visit the study facilities once every week to pick up ready-to-eat beef meals; and complete a brief survey every week to track their consumption of the provided beef meals, and a dietary survey every 4 weeks * Visit the study facilities before and after the 12-week of intervention period for researchers to study them

What is being tested

• Ready-to-eat beef in frozen, 5-oz packages (dietary supplement)
• Ready-to-eat beef in frozen, 1-oz packages (dietary supplement)

Sponsor: University of Nebraska Lincoln · Participants: 240 · Started: Sep 22, 2025

Contact the study team

• Douglas Schultz, PhD · Phone: 402-472-1843
• Aron Barbey, PhD · Phone: 402-472-0168

Official record on ClinicalTrials.gov — NCT06690892

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.