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Split Face Study of the Duration of Local Anesthetics - Fourth Arm

Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery - Fourth Arm

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Male or female ≥ 18 years of age
* Normal skin sensation at both nasal ala assessed by pinprick
* Ability to provide informed consent

Exclusion Criteria:

* Previous adverse reaction to local anesthetic or any components of the local anesthetics being evaluated
* Pregnant or breastfeeding volunteers (assessed by self-report)
* Patients taking monoamineoxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types

About the study

This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for. The investigators will investigate the role of anesthetic volume on the duration of action at highly vascular sites.

What is being tested

• 0.5 ml lidocaine + epinephrine 1:100,000 (drug)
• 1.0 ml lidocaine + epinephrine 1:100,000 (drug)

Sponsor: Weill Medical College of Cornell University · Participants: 35 · Started: Jan 21, 2025

Contact the study team

• Benedict Ho, BA · Phone: 646-962-6647
• Kira Minkis, MD PhD · Phone: 646-962-6647

Official record on ClinicalTrials.gov — NCT06694714

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.