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A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

RecruitingPhase 1/2

A Phase 1/2 Study of BMS-986482 as Monotherapy or Combination Therapy in Participants With Advanced Solid Tumors

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* All participants must have a histologically or cytologically confirmed, advanced, unresectable/metastatic, solid malignancy measurable by RECIST v1.1, and have received, be refractory to, ineligible for, intolerant of, or refused existing therapy(ies) known to provide clinical benefit for the condition of the participant.
* Participant must be ≥ 18 years or the legal age of consent in the jurisdiction in which the study is taking place, inclusive, at the time of signing the ICF.

Exclusion Criteria:

* History of life threatening immune mediated toxicity related to prior T-cell agonist or checkpoint inhibitor therapy, except those that are unlikely to re-occur with standard countermeasures.
* Any significant acute or chronic medical illness which would interfere with study intervention or follow-up in the opinion of the investigator.
* Other protocol-defined Inclusion/Exclusion criteria apply.

About the study

The purpose of this study is to test the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors.

What is being tested

Sponsor: Bristol-Myers Squibb · Participants: 413 · Started: Feb 17, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06697197

Locations in the U.S.

CaliforniaUniversity of California, Irvine (UCI) Health - UC Irvine Medical Center, Irvine
The Angeles Clinic and Research Institute - West Los Angeles Office, Los Angeles
ColoradoLocal Institution - 0008, Aurora (Not yet recruiting)
New JerseyJohn Theurer Cancer Center at Hackensack University Medical Center, Hackensack
New YorkNorthwell Health/ RJ Zuckerberg Cancer Center, Lake Success
North CarolinaLevine Cancer Institute, Charlotte
WashingtonFred Hutchinson Cancer Center, Seattle

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.