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Anticholinergics for Cervical Edema in Labor

Anticholinergics for Cervical Edema in Labor (ACCEL)

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* Primiparous
* Viable single intrauterine pregnancy

  -≥ 34 weeks of gestation
* Ruptured membranes
* Category I tracing at time of inclusion
* Active phase of labor (\>=6 cm of cervix dilation)

Exclusion Criteria:

* Category II or III tracing
* Allergy to the study medication (IV Diphenhydramine)

About the study

The purpose of this study is to is to determine the clinical effectiveness of a single dose of intravenous (IV) medication for the prevention of labor arrest and cesarean delivery in primiparous women undergoing trial of labor.

What is being tested

• Treatment with Diphenhydramine (drug)
• Usual Care (combination product)

Sponsor: The University of Texas Health Science Center, Houston · Participants: 200 · Started: Mar 25, 2025

Contact the study team

• Samantha Antonioli, MD · Phone: (713) 566-5735
• Aaron Roberts · Phone: (713) 500-6412

Official record on ClinicalTrials.gov — NCT06702670

Locations in the U.S.

Conditions

• Dystocia
• Pathologic Dilatation

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.