Home › Persian Gulf Syndrome › NCT06716411
Confirming the Effects of Acupuncture Treatments to Relieve Symptoms of Gulf War Illness
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Deployed to the Gulf Theater of operations (as defined by 38 CFR 3.317, includes Iraq, Kuwait, Saudi Arabia, Bahrain, Qatar, the United Arab Emirates, Oman, the Gulf of Aden, the Gulf of Oman, the Persian Gulf, the Arabian Sea, the Red Sea, and the airspace above all of these locations) between August 1990 and the present date * Have at least 2 of the following symptoms from the 3 CDC clusters of symptom that have lasted for more than 6 months. Each symptom cluster must be characterized as mild-moderate or severe, with at least one symptom in each cluster required to be severe. The clusters are: A. Fatigability: fatigue 24 hours or more after exertion B. Mood and Cognition: feeling depressed; feeling irritable; difficulty thinking or concentrating; feeling worried, tense, anxious; problems finding words; or problems getting to sleep C. Musculoskeletal: joint pain or muscle pain Exclusion Criteria: * Currently enrolled in another clinical trial * Have another disease that likely could account for the symptoms, as determined by our Medical Monitor * Severe psychiatric illness (in the last 2 years psychiatric hospitalization, suicidal attempt, alcohol or substance abuse, use of antipsychotic medication) as measured by the Primary Care Evaluation of Mental Disorder (Prime MD). * Unable to complete the protocol on based on the evaluation of the Medical Monitor.
About the study
This unblinded Phase II clinical trial will test the effects of individualized acupuncture treatments offered in extant acupuncture practices in the community; practitioners will have had at least 5 years of experience plus additional training provided by the study. Veterans with diagnosed symptoms of Gulf War Illness will be randomized to either six months of biweekly acupuncture treatments (group 1, n=100) or 2 months of waitlist followed by weekly acupuncture treatments (group 2, n=100). Measurements were taken at baseline, 2, 4 and 6 months. The primary outcome is the SF-36 physical component scale score (SF-36P).
What is being tested
- Acupuncture (device)
Sponsor: University of Utah · Participants: 200 · Started: Feb 3, 2026
Contact the study team
- Lisa Conboy · Phone: 617-718-1917
Official record on ClinicalTrials.gov — NCT06716411
Locations in the U.S.
| California | University of California, Berkeley, Berkeley (Not yet recruiting) Various, Los Angeles |
| Colorado | Various, Colorado Springs (Not yet recruiting) Various, Denver (Not yet recruiting) |
| Florida | Various, Tampa |
| Massachusetts | Beth Israel Deaconess Medical Center, Boston (Not yet recruiting) |
| Texas | Various, Dallas |
| Utah | University of Utah, Salt Lake City (Not yet recruiting) |
| Virginia | Various, Fairfax (Not yet recruiting) |
| Washington | Various, Seattle (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.