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Vaginal Cuff Anesthesia and Post-Operative Pain Medication Use

A Prospective Randomized Controlled Trial of Vaginal Cuff Anesthesia and Post-Operative Pain Medication Use

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* Patients 18 years and older requiring total laparoscopic hysterectomy with or without bilateral salpingo-oophorectomy for benign conditions
* Presence of malignancy

Exclusion Criteria:

* Conversion to laparotomy

  * Previous multiple abdominal and/or pelvic surgeries
  * Significant medical comorbidities or cardiac history
  * Poor initial Aldrete score4 (\<10)
  * Significant pre-op pain medication use
  * Contraindication to any medication that would be used in the study (Bupivacaine, epinephrine, tramadol or oxycodone)

About the study

The purpose of this study is to determine whether an injection of a local anesthetic (Bupivacaine with epinephrine) in the vaginal cuff prior to closure would result in less immediate postoperative pain medication and increase patient comfort/satisfaction.

What is being tested

• Bupivacain (drug)
• Saline (NaCl 0,9 %) (placebo) (other)

Sponsor: MediSys Health Network · Participants: 100 · Started: Dec 1, 2024

Contact the study team

• Hosam Hanna, MD · Phone: (718) 670-5571

Official record on ClinicalTrials.gov — NCT06719180

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.