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Modeling Blood Management and Hemolytic Risk in Pediatric Heart Surgery

Mathematical Modeling of Salvaged Red Blood Cells-based Blood Management Strategy and Their Hemolytic Risk in Pediatric Cardiac Surgery

Who can join

Ages 0 to 17 · All sexes

Inclusion Criteria:

* pediatric patients under 18 years of age undergoing cardiac surgery with clear prime on cardio-pulmonary bypass (CPB) at Boston Children's Hospital (BCH).

Exclusion Criteria:

* patients with known hemolytic disorders, patients on nitric oxide preoperatively, and patients found to have abnormal coagulation on routine preoperative assessment. Patients receiving heparin, American Society of Anesthesia (ASA) status, apixaban, warfarin, or bivalirudin held appropriately (i.e. for elective surgery) will not be excluded

About the study

This study aims to learn more about blood management in children undergoing heart surgery, such as the right amounts, and the best blood products, to administer. It also aims to develop a mathematical model that may help researchers better predict and treat patients who need blood transfusions during heart surgery.

What is being tested

• blood sampling (other)

Sponsor: Boston Children's Hospital · Participants: 50 · Started: Aug 1, 2025

Contact the study team

• Jocelyn Booth, BSN · Phone: 857-218-4585
• Rachel Bernier, MPH · Phone: 857-218-5348

Official record on ClinicalTrials.gov — NCT06721455

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.