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Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries

Dentin Caries and Polymer-induced Liquid Precursor System (PILP): Adult Safety Study

Who can join

Ages 18 to 64 · All sexes

Inclusion Criteria:

1. Stated willingness to comply with all study procedures and availability for the duration of the study
2. Male or female, aged 18 to sixty-four
3. In good general health as evidenced by medical history (ASA 1 or 2)
4. With at least one posterior tooth with caries to dentin

   1. The tooth must have a pulpal diagnosis of pulpal health (no irreversible pulpitis or periapical radiolucency)
   2. The tooth should have no existing restorations
   3. The caries should be a Class I or class V single surface lesion
   4. The tooth should be planned for restoration with intra-coronal restoration (composite or RMGI restoration)
   5. The tooth should be deemed as needing a restoration based on ICDAS (International Caries Detection and Assessment System)

Exclusion Criteria: Known allergic reactions to components of the study device

About the study

The goal of this clinical trial is to learn if polymer-induced liquid precursor (PILP) can be used safely to treat dentin caries (cavities) in adults. The main question it aims to answer is: Is PILP (conditioner or liner) safe in adult teeth with dental caries? Researchers will compare PILP to a placebo (a look-alike substance that contains no drug) to see if PILP safely treats cavities in teeth.

Participants will: 1) Have PILP or placebo applied to their tooth prior to the placement of a filling in the tooth, 2) Complete two telephone calls within three months of filling placement and 3) Visit the clinic at three months and six months after the placement of the filling.

What is being tested

• PILP Cement (device)
• PILP Conditioner (device)

Sponsor: University of California, San Francisco · Participants: 30 · Started: Feb 1, 2025

Contact the study team

• Jean Star, DDS, MPH · Phone: 415-514-9768
• Jessica Snider, MBA · Phone: 4155146994

Official record on ClinicalTrials.gov — NCT06727110

Locations in the U.S.

Conditions

• Tooth Decay

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.