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Pleural Irrigation With a Novel Devise.

A Pilot Assessment of the Safety and Efficacy of Pleural Irrigation for Retained Pleural Infection Using a Novel Irrigation Device

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Retained pleural effusion identified via bedside ultrasound within the first 24 hours after chest tube insertion
* Patient is contraindicated from receiving intrapleural enzymatic therapy within the first 24 hours after chest tube insertion

Exclusion Criteria:

* Non-infectious cause of pleural fluid analysis findings listed above identified (e.g. malignancy)
* Post-procedural empyema or complicated parapneumonic effusion

About the study

Single-arm pilot trial of the use of intrapleural saline irrigation to treat retained pleural infections for patients with contraindications to standard of care intrapleural enzymatic therapy.

What is being tested

• of intrapleural saline irrigation with CLR irrigator (device)

Sponsor: Beth Israel Deaconess Medical Center · Participants: 10 · Started: May 25, 2025

Contact the study team

• Christine Conley · Phone: 617-632-8386

Official record on ClinicalTrials.gov — NCT06727578

Locations in the U.S.

Conditions

• Pleural Effusion

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.