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Effect of Superior Laryngeal Nerve Blocks on Patient Outcomes in Laryngeal Surgery

Effect of Intraoperative Superior Laryngeal Nerve Blocks on Patient Outcomes in Microdirect Laryngoscopy for Benign Vocal Fold Lesions: A Randomized Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patient is aged 18 years or older at time of consent
* Patient has suspected or confirmed benign vocal fold lesion
* Patient is planning to undergo direct laryngoscopy with excision of the vocal fold lesion
* Patient is English or Spanish speaking
* Patient is not pregnant per self report
* Patient is not incarcerated

Exclusion Criteria:

* Patient is not 18 years of age or older at consent date
* Patient does not speak English or Spanish
* Patient is currently pregnant or plans to become pregnant prior to their study procedure
* Patient has a laryngeal malignancy or found to find a laryngeal malignancy on final pathology
* Patient will not be undergoing direct laryngoscopy with excision of lesion
* Patient is unable to provide consent or complete study activities
* Patient is incarcerated

About the study

Patients undergoing surgery on their vocal cord will either receive a numbing injection to their throat or a saline injection during surgery. Symptoms such as how much coughing or pain patients have after surgery, as well as whether patient's voice gets better will be interrogated.

What is being tested

• Superior laryngeal nerve block - Intervention (Bupivacaine and triamcinolone acetonide suspension) (drug)
• Superior laryngeal nerve block - Placebo (saline) (drug)

Sponsor: Rutgers, The State University of New Jersey · Participants: 28 · Started: Jul 11, 2025

Contact the study team

• Emma Thompson, MD · Phone: 973-972-2548

Official record on ClinicalTrials.gov — NCT06734975

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.