Home › Hot Flashes › NCT06743269
Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women
RecruitingHealthy volunteers welcome
Who can join
Ages 45 to 60 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Females aged 45-60 with hot flashes. * Participants will be recruited from Rochester, MN and surrounding areas. * Non-smokers. * BMI \< 40kg/m\^2. * No history of cardiovascular disease, except for hypertension. Exclusion Criteria: * Detailed medical and social histories will be collected. To allow for ecological validity, participants will not be excluded for use of menopausal hormone therapy or medications affecting cardiovascular function so long as they have been on a consistent regimen for ≥3 months and during the study period. This approach to medications is consistent with recent work in this area. * Participants will be screened for contraindications to inspiratory muscle strength training including, a history of spontaneous pneumothorax, collapsed lung that has not healed fully, a perforated eardrum that has not healed fully, and/or any other condition of the eardrum. * Additional exclusion criteria will include the use of sleep aids (i.e., prescription, melatonin, doxylamine, valerian root, etc.).
About the study
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
What is being tested
- High-Resistance Inspiratory Muscle Strength Training (behavioral)
- Low-Resistance Inspiratory Muscle Strength Training (behavioral)
- POWERbreathe K3 device (device)
Sponsor: Mayo Clinic · Participants: 30 · Started: Mar 27, 2025
Contact the study team
- Pamela Engrav · Phone: (507) 255-6938
- Nancy Meyer · Phone: 507-255-0913
Official record on ClinicalTrials.gov — NCT06743269
Locations in the U.S.
| Minnesota | Mayo Clinic in Rochester, Rochester |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.