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Erector Spinae Plane Block for Acute Back Pain in the Emergency Department

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Adults (age ≥18 years) presenting to the emergency department with isolated low back pain present less than 6 total weeks.

Exclusion Criteria:

* Do not speak English or Spanish as a primary language
* Are incarcerated
* Have a known pregnancy
* Are allergic to amide-type local anesthetics
* Are unable to tolerate positioning for the procedure
* Have a critical illness precluding the ability to perform the procedure.

About the study

The goal of this clinical trial is to learn if an erector spinae plane block (ESPB; a type of nerve block) works to reduce pain in adults presenting to the emergency department with low back pain. It will also learn if the ESPB reduces pain, disability, and return to work at 7 days. The main questions it aims to answer are:

1. Does the ESPB reduce short-term pain in participants with low back pain? 2. Does the ESPB reduce longer-term pain, reduce disability, and improve return to work and activities in participants with low back pain?

Researchers will compare ESPB to a placebo (an injection that does not involve a nerve block) to see if ESPB works to treat low back pain.

Participants will:

Receive either the ESPB or a placebo injection in the emergency department Report their pain scores for up to 120 minutes Report their pain, disability, and return to work at 7 days

What is being tested

• Erector Spinae Plane Block (procedure)
• Sham Procedure (procedure)

Sponsor: Rush University Medical Center · Participants: 62 · Started: Feb 3, 2025

Contact the study team

• Aylin Ornelas Loredo, MMS · Phone: 312-563-0645
• Michelle Santangelo, MS · Phone: 312-563-0645

Official record on ClinicalTrials.gov — NCT06745453

Locations in the U.S.

Conditions

• Low Back Pain

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.