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Electrophysiological Representations of Odor in the Human Brain Study 1

Who can join

Ages 12 to 65 · All sexes

Inclusion Criteria:

* Ages 12 to 65, english speaker, patients undergoing brain surgery for treatment of medically intractable epilepsy

Exclusion Criteria:

* screening for history of smell or taste problems

About the study

Investigating representations of odor intensity in human piriform cortex. To identify a neural representation of perceived odor intensity, it is necessary to dissociate stimulus concentration from perceived intensity. Experiments for this aim will measure human perceptual responses while manipulating intensity independently from concentration using two complementary approaches. In Experiment 1A, we will match perceived intensities across odors of different concentrations, allowing us to identify a neural representation of intensity that is independent of stimulus identity and concentration. In Experiment 1B, we will create conditions of different perceived intensity over constant odor stimuli using adaptation. Approaching the same question from different angles will strengthen the robustness of our findings. Preliminary data suggest that temporal features of the piriform neural response may represent odor intensity.

What is being tested

• odor (behavioral)

Sponsor: Northwestern University · Participants: 28 · Started: Apr 1, 2024

Contact the study team

• Naelly Arriaga, MPH · Phone: 312-503-7244

Official record on ClinicalTrials.gov — NCT06769464

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.