Phenotype-Tailored Lifestyle Intervention for Obesity: A Randomized Trial
Recruiting
Who can join
Ages 18 to 65 · All sexes
Full eligibility criteria
Inclusion: • men or women between 18 to 65 years with obesity (BMI\>30kg/m2). Exclusion: * weight change greater than 3% in the previous 3 months * history of bariatric surgery and bariatric endoscopy * untreated psychiatric disorders including binge eating disorders and bulimia * current use of AOMs * history of use of medications affecting weight or energy intake or energy expenditure in the last 6 months * history of type 1 diabetes mellitus or uncontrolled medical conditions (e.g., uncontrolled hypertension) * women who are pregnant or plan to become pregnant, * any condition that limits their participation in the study * Principal Investigator discretion
About the study
The purpose of this study is to develop an evidence-based precision medicine approach for obesity that enhances weight loss and promotes weight loss maintenance.
What is being tested
- Standard Lifestyle Intervention (SLI) program (behavioral)
- Phenotype-tailored Lifestyle Intervention (PLI) program (behavioral)
Sponsor: Mayo Clinic · Participants: 228 · Started: Jan 22, 2025
Contact the study team
- Megan Schaefer · Phone: 507-266-6004
Official record on ClinicalTrials.gov — NCT06770049
Locations in the U.S.
| Minnesota | Mayo Clinic, Rochester |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.