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Communicating About Nicotine Reduction in Cigarettes
Communicating About Nicotine and Differential Risks of Tobacco Products in Priority Populations
Who can join
Ages 21 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age 21+ years * Current smoker (self-report as having smoked 100 cigarettes in their lifetime and currently smoking on 27+ days out of past 30, expired breath carbon monoxide \[CO\] ≥6ppm to assess regular smoking) * Can speak, read, and write in English * Available for period of study * Willing to try novel research cigarettes Exclusion Criteria: * Pregnancy or lactation * Member of the same household as a study subject * Unwilling to use research cigarettes as part of the trial
About the study
The goal of this clinical trial is to learn how a messaging campaign about reduced nicotine cigarettes and policy, combined with the use of very low nicotine cigarettes (VLNCs), affects smoking behavior and attitudes among adult smokers. The study also aims to assess the efficacy of the messages in different populations, including smokers with past-month serious psychological distress (SPD), low socioeconomic status (SES), and those in neither category.
The primary hypothesis is: exposure to messages in combination with VLNC use will lead to less cigarettes use compared to VLNCs without messages.
Researchers will compare: The effects of receiving VLNCs with messages (treatment group) to receiving VLNCs without messages (control group).
Participants will: Complete a baseline survey and be randomly assigned to one of two groups: treatment (VLNCs + messages) or control (VLNCs only). Attend weekly study visits for surveys, breath samples, and receive supply of VLNCs , either with or without the messaging campaign. Complete brief daily surveys through text messages.
What is being tested
- VLNC messages (behavioral)
- Control message (behavioral)
Sponsor: Georgia State University · Participants: 1,230 · Started: Sep 11, 2025
Contact the study team
- Lyudmila Popova, Ph.D. · Phone: 404-413-9338
Official record on ClinicalTrials.gov — NCT06787937
Locations in the U.S.
| Georgia | Emory University, Atlanta Georgia State university, Atlanta |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.