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Study of ICG Fluorescence Imaging in Open Fracture and Infection Patients

Prospective Observational Study of ICG Fluorescence Imaging in Open Fracture and Infection Patients: Early Comparison With a Novel Imaging Device

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patients 18 years of age or older.
* Open extremity fracture, planning for management with external fixation, internal fixation or joint fusion.
* Fracture Related Infection, planning for management with debridement and possible removal of hardware.
* Will have all planned fracture care surgeries performed by a participating surgeon or delegate.
* Provision of informed consent.

Exclusion Criteria:

* Inability of patient to provide informed consent
* Fracture of the hand.
* Iodine allergy.
* Burns at the fracture site.

About the study

The purpose of this study is to determine whether an indocyanine green (ICG) fluorescence imaging system (cBPI) can be used to provide surgeons with information about bone health or bone blood flow. This will help surgeons better understand the healing potential of bone and relative risk of complication. This is important to help surgeons select the most appropriate treatment for severe traumatic injuries and infections.

What is being tested

• Immunofluorescence Imaging (drug)

Sponsor: Dartmouth-Hitchcock Medical Center · Participants: 10 · Started: Jun 10, 2025

Contact the study team

• Jon Mikael Anderson · Phone: 603-653-3306
• Ida L Gitajn, MD · Phone: 603-650-5000

Official record on ClinicalTrials.gov — NCT06793644

Locations in the U.S.

Conditions

• Fractures
• Accidental Injuries

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.