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Role of Menopause in Thermoregulation
The Influence of Estrogen on the Thermoregulatory Responses to Heat Stress in Pre and Postmenopausal Women
Who can join
Ages 42 to 64 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Women ages 42-64 Exclusion Criteria: * Chron's disease, diverticulitis, or similar gastrointestinal disease * Abnormal resting exercise electrocardiogram (ECG) * Tobacco use * High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor * Assessment * Using hormone therapy * Using hormonal contraceptives
About the study
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men.
Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.
What is being tested
- Elagolix Oral Tablet (drug)
- Estradiol patch (drug)
- cellulose placebo (other)
- placebo patch (other)
Sponsor: Penn State University · Participants: 24 · Started: Mar 1, 2025
Contact the study team
- W. Larry Kenney, Ph.D. · Phone: 814-863-1672
Official record on ClinicalTrials.gov — NCT06798571
Locations in the U.S.
| Pennsylvania | Noll Laboratory, University Park |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.