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Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production

RecruitingHealthy volunteers welcome

Employing Smart Underwear to Measure Gut Microbial Hydrogen Sulfide Production

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
The inclusion/exclusion criteria will identify generally healthy volunteers that are able to ingest the intervention diets. Exclusion criteria based on diseases, medications, allergies, and specific dietary requirements will minimize the risks of adverse reactions to the intervention diets.

Inclusion Criteria:

* Generally healthy volunteers defined as having no major known health conditions (e.g., diabetes, cancer, hypertension, etc.).
* Normal bowel movements, with approximately 1 bowel movement reported per day
* Willing to discuss flatus
* Ages \>18yrs
* Willing to complete the entire study protocol, i.e. eating all of the food that is provided and completing all required measurements.

Exclusion Criteria:

* Self-report or other evidence of diabetes, other endocrine/metabolic abnormality, dyslipidemia, morbid obesity, severe hypertension, chronic kidney disease, liver disease, pulmonary disease, gastrointestinal, and cardiovascular diseases
* Chronic medications for any of the above conditions
* Food allergy that interferes with ability to complete the study
* Food preferences, intolerance, or dietary requirements that would interfere with diet adherence
* Planned dietary changes during the study period
* Lack of appropriate food refrigeration and preparation equipment (e.g.- oven or microwave)
* Pregnancy or planned pregnancy in the next month
* Physical measurements: BMI \> 35 kg/m2

About the study

The purpose of this study is to evaluate the ability of a wearable Smart Underwear prototype device to quantify diet-induced changes in gut microbial hydrogen sulfide (H₂S) production. The core design is a single-site, 2-period, crossover feeding study with 6-day diet periods and an approximately 11-day washout period. Participants are fed each of two isocaloric diets designed to contrast gut microbial H₂S production (i.e., a high cysteine vs. low cysteine diet), in a random order.

What is being tested

Sponsor: University of Colorado, Denver · Participants: 25 · Started: May 21, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06802276

Locations in the U.S.

ColoradoUniversity of Colorado Anschutz Medical Campus, Aurora

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.