Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia

Inclusion Criteria:

* Recommended aspirin for pre-eclampsia prevention by OB/GYN or MFM specialist based on ACOG and USPSTF guidelines (1 high risk factor, 2+ moderate risk factors)

  * Willingness to adhere to aspirin therapy
  * Willingness to undergo 2h OGTT for serum and urine collection in addition to survey collection, indirect calorimetry, body composition measures, neonatal measures, etc.
  * Gestational age at enrollment \<16 weeks
  * Ability to speak, read, and communicate via English

Exclusion Criteria:

* Type 2 Diabetes Mellitus

  * Type 1 Diabetes Mellitus
  * Current gestational diabetes mellitus
  * Current/active platelet disorder or bleeding diathesis (thrombocytopenia of any etiology, idiopathic thrombocytopenic purpura/ITP, thrombotic thrombocytopenic purpura/TTP, von Willebrand disease, etc.)
  * Thrombophilia
  * Current use of NSAID for other indication (indomethacin, ibuprofen, etc.)
  * Current use of other immune-modulating agents and biologics (hydroxychloroquine, azathioprine, 6-mercaptopurine, IL-6 inhibitors, etc.)
  * Current or recent use of steroids
  * Current use of prophylactic or therapeutic anticoagulation
  * Medical contraindication to aspirin therapy
  * Molar pregnancy
  * Renal disease
  * Inability or unwillingness to give informed consent
  * Current psychiatric illness/social situation that would limit compliance with study requirements, as determined by the principal investigators