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Understanding Perinatal Spinal Cord Injury

Understanding Perinatal Spinal Cord Injury: Comprehensive Assessment and Personalized Neuromodulation for Improved Whole-Body Functions

Who can join

Ages 3 to 8 · All sexes

Inclusion Criteria:

* diagnosed with a perinatal (injured in utero or at birth), upper motor neuron spinal cord injury involving cervical spinal levels
* discharged from inpatient hospitalization/inpatient rehabilitation

Exclusion Criteria:

* Botox use within the past 3 months
* Current oral baclofen or baclofen pump use
* Musculoskeletal impairment limiting range of motion (e.g. severe scoliosis), unhealed fracture, or other medical impairment limiting study participation
* History of allodynia (heightened skin sensitivity typically at the level of the lesion site)
* History of scoliosis surgery
* Ventilator-dependence
* Unwillingness to wean from daytime use of thoroco/lumbosacral orthosis and ankle/foot orthosis during the intervention period

About the study

The purpose of this study is to deepen our understanding of children who have a cervical spinal cord injury obtained in utero or at birth and examine the effects of tailored activity-based recovery training (ABRT) in combination with transcutaneous spinal cord stimulation (scTS). This is a within subjects, pre-post design study. Neurophysiological, sensorimotor, and autonomic assessments will occur pre, interim, and post 40 sessions of ABRT in conjunction with scTs.

What is being tested

• Activity-Based Recovery Training (other)
• Transcutaneous Spinal Cord Stimulation (device)

Sponsor: University of Louisville · Participants: 6 · Started: Jan 9, 2024

Contact the study team

• Lisa R. Clayton, CCRP · Phone: 502-569-7996

Official record on ClinicalTrials.gov — NCT06808035

Locations in the U.S.

Conditions

• Spinal Cord Injuries

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.