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Acceptance and Commitment Therapy Integrated Vestibular Rehabilitation (ACTIVE) RCT

Acceptance and Commitment Therapy Integrated Vestibular Rehabilitation (ACTIVE) for mTBI: A Targeted Randomized Controlled Trial

Who can join

Ages 18 to 49 · All sexes

Inclusion Criteria:

* 18-49 years of age
* Normal/corrected vision
* Diagnosed with mTBI per military clinical practice guidelines (CPGs) that occurred over 8 days prior to consent as determined by a multi-domain assessment performed by a licensed healthcare professional.
* mTBI-related symptoms and/or impairments in at least one or more areas, including vestibular (dizziness, imbalance), psychological health (anxiety, depression, stress), cognitive (memory problems), headache/migraine, ocular, or sleep. as determined by self-report.

Exclusion Criteria:

* History of vestibular disorder (e.g., benign paroxysmal positional vertigo, unilateral or bilateral vestibular hypofunction) as determined by patient self-report.
* History of neurological disorder (e.g., epilepsy, multiple sclerosis) as determined by self-report.
* Cervical spine injury or dysfunction (i.e., limited range of motion; ROM) as determined by self-report.
* Previous moderate to severe TBI as determined by self-report.
* \< 8 days following current mTBI as determined by self-report.
* Currently pregnant as determined by self-report.

About the study

The primary objective of this multi-site randomized clinical trial (RCT) is to compare Acceptance and Commitment Therapy Integrated Rehabilitation (ACT) with usual care rehabilitation (CONTROL) in 250 individuals with mTBI-related symptoms attributable to mild traumatic brain injury (mTBI) treated at one of two sites (1) the University of Pittsburgh Medical Center, or (2) the Intrepid Spirit Center, Carl R. Darnall Army Medical Center, Fort Hood, Texas. Both interventions will be delivered weekly over 4 weeks. Assessments will be administered prior to the start of treatment (Baseline) and at 4-weeks, 3- and 6-months following the completion of treatment.

What is being tested

• Acceptance and Commitment Therapy Integrated Rehabilitation (ACT) (behavioral)
• Usual Care Rehabilitation (behavioral)

Sponsor: University of Pittsburgh · Participants: 250 · Started: Feb 27, 2025

Contact the study team

• Anthony Kontos, PhD · Phone: 814-615-2163
• Courtney Perry, MS · Phone: 412-904-1298

Official record on ClinicalTrials.gov — NCT06819904

Locations in the U.S.

Conditions

• Concussion

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.