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The Effect of Uterine Entry In Fetoscopic Laser Photocoagulation for Twin-To-Twin Transfusion Syndrome

The Effect of Entry Technique on Chorioamniotic Membrane Separation in Fetoscopic Laser Photocoagulation for Twin-To-Twin Transfusion Syndrome

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* Patients who are eligible and elect to undergo fetoscopic selective laser photocoagulation for complicated monochorionic-diamniotic twin pregnancies with twin-to-twin transfusion syndrome.
* Patients will be between 16 0/7 weeks and 26 0/7 weeks gestational age.

Exclusion Criteria:

* Patients who do not elect to undergo fetoscopic laser photocoagulation for the treatment of complicated monochorionic-diamniotic twin pregnancies with twin-to-twin transfusion syndrome.
* Triplets and higher order multiple gestations.
* Patients who are less than 16 0/7 weeks or greater than 26 0/7 weeks gestational age.
* Patients with a short cervix (less than 1.5 cm).
* Patients with a known subchorionic hemorrhage.

About the study

The purpose of this study is to evaluate whether the entry technique surgeons use to get inside the uterus to perform fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome has an effect on the rates of chorioamniotic membrane separation.

What is being tested

• Fetoscopic Laser Photocoagulation (procedure)

Sponsor: Baylor College of Medicine · Participants: 216 · Started: Mar 14, 2025

Contact the study team

• Ahmed Nassr, MD, PhD · Phone: 832-826-7449
• Becky Johnson, MS, CCRP · Phone: 832-826-7451

Official record on ClinicalTrials.gov — NCT06829901

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.