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The ROAR Study: Reactive Oxygen Species and Reproduction

Who can join

Ages 18 to 43 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. Female age 18-43 years
2. Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
3. Male partners 18 years of age or older.
4. Must be a registered patient at UCSF Center for Reproductive Health
5. Patient and partner must both be physically present on the day of retreival

Exclusion Criteria:

1. Female partner age 44 or older
2. Planning fresh transfer (hybrid PGS cycle)
3. Cleavage stage biopsy
4. Planning to use frozen sperm

About the study

This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.

What is being tested

• Oxidative stress markers (diagnostic test)

Sponsor: University of California, San Francisco · Participants: 1,100 · Started: Jul 7, 2025

Contact the study team

• Elena Hoskin, BS · Phone: (415) 885-3598

Official record on ClinicalTrials.gov — NCT06831019

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.