Home › NCT06831110

Aquagenic Wrinkling Prediction

Using Aquagenic Wrinkling to Predict CF Carrier State

Who can join

Ages 18 to 24 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Interested in participating in other CF Carrier-related research studies.

Exclusion Criteria:

* CF patient status
* Unable to speak English
* Unable to provide written informed consent
* Prisoner status
* An open wound on either hand
* A tattoo on either hand
* Missing any portion of either hand
* Diagnosis of Diabetes
* Diagnosis of Hyperhidrosis
* Diagnosis of Raynaud's Disease
* Diagnosis of Atopic Dermatitis
* Regularly taking ACE inhibitors or angiotensin receptor blockers

About the study

The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status.

Participants will complete one visit where they will undergo an aquagenic wrinkling procedure to see how their hands respond.

What is being tested

• Aquagenic Wrinkling (procedure)

Sponsor: University of Iowa · Participants: 2,000 · Started: Mar 6, 2025

Contact the study team

• Philip M Polgreen, MD · Phone: 319-384-6194
• Shelby L Francis, PhD · Phone: 319-678-8037

Official record on ClinicalTrials.gov — NCT06831110

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.