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Post-incision Antimicrobial Wash vs C. Acnes in Shoulder Arthroplasty

Application of a Novel Antimicrobial Wash Versus Hydrogen Peroxide Versus Povidone-iodine to the Dermis and Incidence of Cutibacterium Acnes During Shoulder Arthroplasty: A Randomized Controlled Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Indicated and scheduled for primary shoulder arthroplasty.
* Chronic severe glenohumeral osteoarthritis, avascular necrosis, post traumatic osteoarthritis, rotator cuff arthropathy,
* Ability to read and understand English
* Age ≥18 years
* Patient failed ≥6 weeks of conservative treatment, which included non-steroidal anti-inflammatory drugs (NSAIDS)

Exclusion Criteria:

* Patient with history of prior native shoulder septic arthritis or infection
* Prior surgery of affected shoulder
* Proximal Humerus Fracture
* Active infection
* Cancer
* Autoimmune and rheumatologic disorders, including rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus
* History of allergic reaction to citric acid-derived products

About the study

The purpose of this randomized controlled trial is to determine the effect of post-incision wash using various novel antimicrobial solutions on the rate of positive C. Acnes cultures collected from adults undergoing primary shoulder replacement surgery. Subjects will be randomly assigned in a 1:1:1:1 fashion to groups that will receive one of the following treatments:

* Post-incision application of Xperience Antimicrobial wash (NextScience, Jacksonville, FL) * Post-incision application of 3% hydrogen peroxide * Post-incision application of 10% povidone-iodine (betadine) * No post-incision treatment (control)

The investigators hypothesize that the subjects treated with the antimicrobial solutions after initial incision will have lower rates of positive C. Acnes cultures. The investigators also hypothesize that post-incision application of Xperience Antimicrobial wash and Betadine will have an equal reduction in the incidence of C. acnes as Hydrogen Peroxide.

What is being tested

• Povidone-Iodine (device)
• Hydrogen Peroxide (device)
• Xperience Antimicrobial Wash (device)
• Bacterial Cultures (diagnostic test)
• Shoulder Arthroplasty (procedure)

Sponsor: Henry Ford Health System · Participants: 150 · Started: May 5, 2025

Contact the study team

• Chimdindu Obinero, BS · Phone: 678-230-8592
• Jared Mahylis, MD · Phone: 313-916-2181

Official record on ClinicalTrials.gov — NCT06831422

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.