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Genetic Risk Factor for Heat Stroke
Exploring a Common Genetic Risk Factor for Heat Stroke and Dehydration
Who can join
Ages 18 to 60 · All sexes
Full eligibility criteria
Inclusion Criteria: * Previously genotyped as a CF carrier or control * Comfortable speaking/reading English Exclusion Criteria: * Previously genotyped as a CF patient * Diagnosis of Type 1 or Type 2 diabetes * History of heart attack, stroke, heart failure, or atherosclerosis * Currently pregnant * Currently taking beta blockers or diuretics * Prisoner status * Unable to provide own written informed consent
About the study
The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults.
The primary aim of the study is to estimate the risk of electrolyte disorders attributable to the CF carrier state in a genotyped cohort.
This will be accomplished with two smaller projects- Aim 1 and Aim 2.
Aim 1 will consist of 100 CF Carriers and 100 age- and sex-matched controls. Participants in this aim will be asked to complete a Participant Info and Temperature Survey consisting of questions about race, ethnicity, medical history, and how they experience heat.
Aim 2 will consist of a subset of 25 CF Carriers and 25 age- and sex-matched controls from Aim 1. Participants in this aim will be scheduled for a visit to complete a heat challenge. At this visit, they will also complete the Participant Info and Temperature Survey. They will also sit in a sauna at 62 - 63 degrees Celsius for 45 minutes.
What is being tested
- Heat Challenge (procedure)
Sponsor: University of Iowa · Participants: 200 · Started: Nov 19, 2025
Contact the study team
- Aaron Miller, PhD · Phone: (319) 335-3053
- Shelby L Francis, PhD · Phone: 319-678-8037
Official record on ClinicalTrials.gov — NCT06847256
Locations in the U.S.
| Iowa | University of Iowa Health Care, Iowa City |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.