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Randomized Clinical Trial of TUNE In 3.0: A Social/Emotional Program for Adults With Autism Spectrum Disorder
ASPE Subproject - Training to Understand and Navigate Emotions and Interactions (TUNE In)
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * 18 years of age or older * Meet ASD diagnostic criteria supported by an outside diagnostic evaluation and/or by the clinical and developmental information gathered from a phone screen * Be willing to complete screening surveys (outcome measures) * Social Responsiveness Score, Second Edition, self-report SRS survey score of greater than or equal to 60 Exclusion Criteria: * Severe self-injurious or aggressive behaviors; or with suicidal or homicidal ideation or behaviors (e.g. suicide attempt) within the last 6 months * Major mood episode (major depressive episode, manic episode), psychotic symptoms, or a psychiatric hospitalization within the last 6 months * A history of intellectual disability or low Shipley-2 score
About the study
The purpose of this study is to test a novel, cognitive behavioral treatment strategy to improve social functioning in adults with autism spectrum disorder.
The treatment, named TUNE In (Training to Understand and Navigate Emotions and Interactions), includes components to address the many behavioral domains involved in social functioning, including social motivation, social anxiety, social cognition, social skills, and generalization of the skills to community settings.
The Investigators will test the efficacy of TUNE In to improve social functioning in adults with autism spectrum disorder (ASD), using a randomized controlled trial using the SRS-2 as the primary outcome measure.
What is being tested
- TUNE In: Training to Understand and Navigate Emotions and Interactions (behavioral)
Sponsor: University of Pennsylvania · Participants: 40 · Started: Mar 24, 2025
Contact the study team
- Edward Brodkin, M.D · Phone: 215-746-4100
Official record on ClinicalTrials.gov — NCT06859918
Locations in the U.S.
| Pennsylvania | Brodkin Lab: Perelman School of Medicine, Department of Psychiatry, University of Pennsylvania, Philadelphia |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.