WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)
Obesity and Type 2 Diabetes: Bariatric Surgery Effects on Brain Function -Part 2 (WISE-2B Brain Study)
Who can join
Ages 20 to 75 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Between age: 20-75 yrs, English speaking, Physically mobile * Body Mass Index (BMI) \>35 kg before surgery * Compatible of MRI Scanning * Willing to give a small blood sample * Capable of providing informed consent Exclusion Criteria: * Prior or current neurological disorder * Major psychiatric disturbance * Unstable medical conditions (cancer) * MRI contraindications (claustrophobia, metal implants, waist/torso circumference)
About the study
The goal of the study to understand the effects of weight loss and improvements in diabetes following bariatric surgery on brain function and thinking. This study will also examine whether non-invasive transcutaneous vagal nerve stimulation (tVNS) intervention initiated 30 days post-surgery improves brain function and thinking. The study does NOT cover any costs associated with bariatric surgery.
What is being tested
- tVNS (behavioral)
- Complete Vagotomy (procedure)
- Anterior Vagotomy (procedure)
Sponsor: University of Florida · Participants: 120 · Started: Nov 10, 2025
Contact the study team
- Keyanni J Johnson · Phone: 3522945618
- Ronald Cohen, PhD · Phone: 352-295-5840
Official record on ClinicalTrials.gov — NCT06861790
Locations in the U.S.
| Florida | University of Florida - College of Public Health and Health Professions, Gainesville |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.