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Weight Loss Through Mayo Clinic Diet

Weight Loss Through Mayo Clinic Diet; a Prospective Pilot Study

Who can join

Ages 18 to 64 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Males and females (non-pregnant) 18-64
* BMI \> or = to 25 kg/m2
* Ability to read and understand English. (as the Mayo Clinic Diet book and app are only available in English)

Exclusion Criteria:

* Have a current diagnosis of melanoma or cancer diagnosis
* Currently breastfeeding
* Pregnant, or planned to be pregnant within 6 months
* Have a diagnosis of Type 1 or 2 Diabetes Mellitus
* Had weight loss surgery within the last year
* Currently participating in another lifestyle weight loss program or taking medications for weight loss
* Have lost 5% or more of their weight in the last six months
* Have a history of eating disorders
* Have planned surgery in the next 6 months.

About the study

The purpose of study is to evaluate the efficacy of the Mayo Clinic Diet in clinically significant weight loss (\>5%) versus usual care. We also wish to evaluate the feasibility, barriers to completion, and sustainability of this intervention at the 24, and 52-week marks. Lastly, we aim to study the change in participants body composition and quality of life at the end of this intervention.

What is being tested

• Mayo Clinic Diet (behavioral)
• Usual Care (behavioral)

Sponsor: Mayo Clinic · Participants: 250 · Started: Mar 5, 2025

Contact the study team

• Family Medicine Research Study Coordinators · Phone: 507-422-6823

Official record on ClinicalTrials.gov — NCT06862375

Locations in the U.S.

Conditions

• Obesity

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.