Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Trial

Recruiting

Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Randomized Controlled Trial

Who can join

Ages 18 and older · All sexes

Full eligibility criteria

Inclusion Criteria:

* Life expectancy of at least 6 months
* Lesions in the proximal femur (femoral neck, intertrochanteric region, subtrochanteric region, and combinations thereof)
* Low or intermediate risk for perioperative morbidity and/or mortality
* No more than 75% and no less than 25% bone loss
* Mutual (patient and physician) decision to perform surgical management of an impending or realized pathologic fracture due to MBD of the proximal has been made.

Exclusion Criteria:

* Lesions isolated to the femoral neck
* Lesion with any femoral head involvement
* High risk for perioperative morbidity and/or mortality
* Multidisciplinary decision that resection of the entire lesion would be indicated

About the study

The goal of this clinical trial is to find out if removing and replacing part of the hip bone works better than using metal hardware to stabilize the bone in patients whose cancer has spread to the hip. The main questions are:

1. Does removing and replacing part of the bone work better than just stabilizing it with metal hardware? 2. Does removing and replacing the bone help reduce problems like cancer coming back or the metal hardware breaking?

Researchers will compare two treatments: using metal rods and plates to stabilize the bone (internal fixation) versus removing part of the bone and possibly replacing the hip joint (resection and reconstruction) to see if the second option causes fewer problems.

Participants will:

* Be randomly assigned to one of two groups (internal fixation or resection and reconstruction). * Have one of the two surgeries based on which group they're in. * Go to follow-up appointments with the study doctor at 2 weeks, 6 weeks, 4 months, 6 months, 9 months, and 12 months after surgery.

What is being tested

Internal Fixation (procedure)
Resection and reconstruction (procedure)

Sponsor: Michelle Ghert, MD · Participants: 334 · Started: Feb 1, 2025

Contact the study team

Olivia Virag, MA · Phone: 905- 521-2100
Hadia Farrukh · Phone: 905- 521-2100

Official record on ClinicalTrials.gov — NCT06863129

Locations in the U.S.

Colorado	University of Colorado Hospital, Aurora
Indiana	Parkview Packnett Family Cancer Institute, Fort Wayne
Ohio	University of Cincinnati Medical Center, Cincinnati
Oregon	Oregon Health and Science University Hospital, Portland

Conditions

Bone Diseases

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.