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Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors

Recruiting

Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors (LIVE-WEL)

Who can join

Ages 55 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Enrollment within 3-months +2 weeks of a first-time ischemic or hemorrhagic stroke
* 24-item HDRS score \< 15 indicating subthreshold depression defined as the absence of depressive symptoms or presence of mild symptoms of depression
* Single person income less than or equal to $45,000
* Residing in a community residence
* Ability to speak and read in English or Spanish
* Mini-MoCA score \> or equal to 11

Exclusion Criteria:

* Stroke event unrelated to vascular risk factors (e.g., drug use) or transient ischemic attack
* 24-item HDRS score \> or equal to 15 indicating moderate to severe depression
* Actively participating in psychotherapy
* high suicide risk or severe psychiatric illness (e.g., bipolar disorder and active psychosis) and/or actively taking antipsychotics
* Diagnosed dementia and/or currently taking cognitive enhancers, amyloid-targeting medications, or orexin receptor antagonists
* Patient Health Questionnaire 9 score \> or equal to 10 and/or answers positive to Q9
* Diagnosed aphasia and/or severe cognitive impairments
* high-risk alcohol or drug misuse
* receiving medications for mood disorders and a change in dose or type within the last 4 weeks

About the study

The overall objective of the project is to determine the effectiveness of tele-delivered behavioral activation (BA) by trained lay counselors (Tele-BA-S) to prevent Post-stroke depression (PSD) in low-income, older stroke survivors with subthreshold depression (SD).

What is being tested

Sponsor: The University of Texas Health Science Center, Houston · Participants: 350 · Started: Apr 10, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT06864715

Locations in the U.S.

TexasThe University of Texas Health Science Center at Houston, Houston

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.