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New York Better Breathing Study

Lung Cancer Better Breathing Study

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Age ≥ 18 years of age.
* Able to speak, read and comprehend the English language
* Self-identify as non-Hispanic Black or White.
* Are \< 24 months of histologically confirmed invasive, non-metastatic, lung cancer diagnosis.
* Have received surgical treatment (primarily stage I, II and III) and have completed all cancer treatments (surgery, chemotherapy, radiation).
* Willing to provide biospecimen samples for the study (blood) which will be collected in the comfort of the patient's home by a mobile phlebotomy group.
* Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure.

Exclusion Criteria:

* Participant has in situ (stage 0) or metastatic (stage IV) disease at study entry.
* Has contraindications for respiratory muscle training (e.g., recent pulmonary embolism, aortic aneurysm, current pneumothorax).
* Is actively engaging in a structured exercise program and/or meeting exercise guidelines.
* Unwilling or unable to follow protocol requirements.
* Any condition which in the investigator's opinion deems the participant an unsuitable candidate to participate in the study.

About the study

This clinical trial evaluates the effects of whether breathing exercises at home can reduce symptoms and help stage I-III lung cancer survivors stay active. Over 70% of lung cancer survivors have trouble breathing, feel tired, and have lower levels of fitness. This is often because their breathing muscles are weaker after surgery. Many survivors find it hard to exercise, which affects their quality of life and overall survival. A training program to strengthen these muscles might reduce breathing problems, lower fatigue, and improve quality of life. Staying active could also help boost the immune system to fight cancer. Respiratory muscle training (RMT) involves a series of breathing and other exercises that are performed to improve the function of the respiratory muscles through resistance and endurance training. Participating in a home-based RMT intervention may reduce symptoms from cancer or treatment in lung cancer survivors.

What is being tested

• Biospecimen Collection (procedure)
• Electronic Health Record Review (other)
• Medical Device Usage and Evaluation (other)
• Questionnaire Administration (other)
• Respiratory Muscle Training (procedure)
• Sham Intervention (procedure)

Sponsor: Roswell Park Cancer Institute · Participants: 100 · Started: Apr 20, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT06869447

Locations in the U.S.

Conditions

• Lung Cancer

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.