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Pilot Neurobehavioral Therapy for Functional Neurological Disorder

A Pilot Randomized Controlled Trial (RCT) of Neurobehavioral Therapy (NBT) vs Standard Medical Care (SMC) for Functional Neurological Disorder (FND)

Who can join

Ages 18 to 100 · All sexes

Inclusion Criteria:

* Individuals diagnosed with Motor Functional Neurological Disorder (mFND)
* Individuals aged 18-100 years
* At least 1 mFND symptom during the year prior to enrollment

Exclusion Criteria:

* Current or past year self-injurious behavior
* Current suicidality (PHQ-9 question 9 rated as 1 or above)
* Current or past year psychosis
* Pending litigation or current application for long term disability
* Active substance or alcohol use disorders (dependence), at the discretion of the investigator if they preclude participation in the study
* Serious illness requiring systemic treatment or hospitalization; the participant either completes therapy or is clinically stable on therapy, for at least 30 days prior to study entry
* Inability to fill out the self-report surveys
* Inability or unwillingness to participate in NBT and assigned homework
* Currently enrolled in NBT aimed at mFND

About the study

The goal of this pilot randomized clinical trial is to learn if Neurobehavioral Therapy (NBT) works to treat motor functional neurological disorder (mFND) (also referred to as functional motor disorder).

The main questions it aims to answer are:

* Does NBT lower mFND symptoms? * Does NBT lower common co-occurring symptoms and improve functioning?

Researchers will compare NBT to standard medical care (SMC).

Participants will be randomized to receive either:

* 12 weekly sessions of NBT, along with their SMC, * or continue receiving their SMC as provided by their treating clinicians. * all participants. regardless of group assignment, will complete a total of five in-clinic visits at the following time points: Baseline, 6 weeks, 12 weeks, 8 Months and 12 Months for self-report surveys to assess functional status, quality of life and mFND symptoms.

What is being tested

• Neuro-behavioral Therapy (behavioral)
• Standard Medical Care (SMC) (other)

Sponsor: Rhode Island Hospital · Participants: 40 · Started: Sep 25, 2024

Contact the study team

• Alexis Sr. Clinical Research Assistant · Phone: 401-606-4651
• Deepica Clinical Research Program Coordinator · Phone: 401-606-4655

Official record on ClinicalTrials.gov — NCT06873698

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.