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Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease
Multi-Site Randomized Controlled Trial of A Multidisciplinary Intervention for Adults With Chronic Graft Versus Host Disease
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Adult patients (≥ 18 years) who have undergone allogeneic HCT * Have moderate to severe cGVHD based on patient-report * Have ability to participate in English or Spanish language group telehealth intervention. Exclusion Criteria: * Patients with mild cGVHD based on their self-report. * Patients with a major untreated psychiatric or cognitive condition which the treating oncology clinicians believes interferes with the capacity to provide informed consent. * Patients with active relapsed disease requiring therapy.
About the study
The goal of this study is to demonstrate the efficacy of a multidisciplinary group-based telehealth intervention (HORIZONS) compared to minimally enhanced usual care for improving self-management and quality of life for hematopoietic stem cell transplant (HSCT) survivors living with chronic graft-versus host disease, and to identify critical facilitators and barriers for HORIZONS implementation and adoption.
What is being tested
- HORIZONS Intervention (behavioral)
- Minimally enhanced usual care (behavioral)
Sponsor: Massachusetts General Hospital · Participants: 350 · Started: Aug 13, 2025
Contact the study team
- Lara Traeger PhD · Phone: 304-284-3012
- Areej El-Jawahri MD · Phone: 617-721-4000
Official record on ClinicalTrials.gov — NCT06910969
Locations in the U.S.
| Florida | University of Miami Sylvester Comprehensive Cancer Center, Miami |
| Massachusetts | Massachusetts General Hospital, Boston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.