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Maternal Left Lateral Position in Fetal Growth Restriction

Impact of Maternal Left-Lateral Recumbent Positioning in Pregnancies With Fetal Growth Restriction

Who can join

Ages 18 to 65 · Women

Inclusion Criteria:

* Pregnant persons between 18 - 65 years of age, with a diagnosis of fetal growth restriction, with an estimated fetal weight less than tenth percentile
* Participants with a singleton pregnancy between 24- and 34-weeks' gestational age
* Participants with fluency in English or Spanish language

Exclusion Criteria:

* Patients with a known history of deep vein thrombosis, pulmonary embolism, or hypercoagulability disorder
* Patients with a pre-pregnancy BMI greater than 40
* Pregnancy with severe abnormality in umbilical artery Doppler flow, including absent end-diastolic flow (AEDF) and reverse end-diastolic flow (REDF)
* Patients receiving anticoagulation therapy
* Pregnancy with suspected chromosomal anomalies or a multifetal pregnancy
* Patients with an active smoking status during pregnancy

About the study

The goal of this clinical trial is to learn if maternal left-lateral positioning in pregnancy works to treat fetal growth restriction. This study will also help us learn about the effects of left-lateral positioning on maternal metabolomics, maternal mental health, fetal cardiac function, and delivery outcomes. The main questions it aims to answer are:

* Does maternal left-lateral position in a pregnancy with fetal growth restriction improve the baby's growth? * How are maternal metabolomics, delivery outcomes, maternal mental health, and fetal cardiac function impacted by maternal left-lateral position? Researchers will compare the intervention group to pregnancies with fetal growth restriction that receive standard of care (without left-lateral positioning) to see if left-lateral position improves fetal biometry in fetal growth restriction.

Participants will:

* Practice left-lateral position every day for 4 hours (cumulatively) with 10-mins stretching after every hour of left-lateral position, or continue to receive standard of care * Visit the clinic once after 4 weeks for a follow-up research visit, and at the time of delivery

Tracking of the physical activity and adherence to left-lateral position at home in intervention group A will be done through a fitbit (smart watch) given during enrollment. A fitbit will also be given to participants in intervention group B, receiving standard of care, to monitor their physical activity trends at home.

What is being tested

• Left lateral recumbent positioning (behavioral)

Sponsor: University of Colorado, Denver · Participants: 100 · Started: Jul 28, 2025

Contact the study team

• Hannah E Vincent, PhD · Phone: 7209191019

Official record on ClinicalTrials.gov — NCT06919692

Locations in the U.S.

Conditions

• Fetal Growth Retardation

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.